When large VSDs
are uncorrected, the resulting pulmonary hypertension can reverse
the shunting of blood across the defect. In other words, the
previously "left to right" shunt becomes "right to
left." This type of complication is called Eisenmenger's
syndrome.
Here, the deoxygenated blood crosses to the left and mixes with the oxygenated blood coming from the lungs. This mixed blood, with a decreased level of oxygen, is then sent to the rest of the body.
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